Dynamical analysis of astrocyte-induced neuronal hyper-excitation

This paper introduces a computational model of integrated information in bidirectional neuron–astrocyte communication. Dynamical analysis and transfer process are studied when stimulation metabotropic glutamate is loaded into neuron astrocyte coupled model, respectively. The results show that the loading stimulus coupling strength cause neuronal hyper-excitation, which some way linked to epileptic instabilities. A period sustained firing activities could continue after cessation because how long it takes for calcium concentration decrease steady state. Additionally, we also found reducing feedback effectively inhibit seizure-like from aspect energy consumption somatic firing.